Abstract
An exploratory chemical effort has been undertaken to develop a novel series of compounds as selective CB(1) agonists. It is hoped that compounds of this type will have clinical utility in pain control, and cerebral ischaemia following stroke or traumatic head injury. We report here medicinal chemistry studies directed towards the investigation of a series of 1-substituted-indole-3-oxadiazoles as potential CB(1) agonists.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Analgesics / chemical synthesis*
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Analgesics / chemistry
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Analgesics / metabolism
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Analgesics / pharmacology*
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Animals
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Binding Sites
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Cannabinoids / metabolism*
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Drug Design
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Hydrogen Bonding
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Hydrophobic and Hydrophilic Interactions
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Indoles / chemical synthesis*
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Indoles / chemistry
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Indoles / metabolism
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Indoles / pharmacology*
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Inhibitory Concentration 50
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Mice
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Oxadiazoles / chemical synthesis*
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Oxadiazoles / chemistry
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Oxadiazoles / metabolism
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Oxadiazoles / pharmacology*
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Rats
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Receptor, Cannabinoid, CB1 / agonists*
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Receptor, Cannabinoid, CB1 / chemistry
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Receptor, Cannabinoid, CB1 / metabolism
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Substrate Specificity
Substances
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Analgesics
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Cannabinoids
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Indoles
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Oxadiazoles
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Receptor, Cannabinoid, CB1